Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins.

  title={Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins.},
  author={Mari D. Heghinian and Monica A. Mejia and David J Adams and Tanja A Godenschwege and Frank Mar{\'i}},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={29 3},
Nicotinic acetylcholine receptors (nAChRs) play a pivotal role in synaptic transmission of neuronal signaling pathways and are fundamentally involved in neuronal disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. In vertebrates, cholinergic pathways can be selectively inhibited by α-conotoxins; we show that in the model organism Drosophila, the cholinergic component of the giant fiber system is inhibited by α-conotoxins MII, AuIB, BuIA, EI, PeIA, and ImI. The… CONTINUE READING