Inhibition of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation.

@article{Nakai2003InhibitionOC,
  title={Inhibition of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation.},
  author={Kuniharu Nakai and Susumu Tazuma and Tomoji Nishioka and Kazuaki Chayama},
  journal={Biochimica et biophysica acta},
  year={2003},
  volume={1632 1-3},
  pages={
          48-54
        }
}
Pigment gallstones have been reported to be closely associated with biliary tract infection. We previously reported that addition of unconjugated bilirubin (UCB), which is deconjugated by beta-glucuronidase in infected bile, could enhance cholesterol crystal formation in supersaturated model bile (MB). The present study evaluated the effect of beta-glucuronidase on the processes of pigment gallstone formation and cholesterol crystallization. Supersaturated MB (taurocholate/lecithin/cholesterol… CONTINUE READING
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