Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

@article{Xia2008InhibitionOC,
  title={Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.},
  author={Fuzhen Xia and Li Xie and Anton Mihic and Xiaodong Gao and Yi Chen and Herbert Y Gaisano and Robert G. Tsushima},
  journal={Endocrinology},
  year={2008},
  volume={149 10},
  pages={5136-45}
}
Insulin secretion from pancreatic beta-cells is mediated by the opening of voltage-gated Ca2+ channels (CaV) and exocytosis of insulin dense core vesicles facilitated by the secretory soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein machinery. We previously observed that beta-cell exocytosis is sensitive to the acute removal of membrane cholesterol. However, less is known about the chronic changes in endogenous cholesterol and its biosynthesis in regulating beta… CONTINUE READING
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