Inhibition of cholesterol absorption in rats by plant sterols.

  title={Inhibition of cholesterol absorption in rats by plant sterols.},
  author={Ikuo Ikeda and Kouichi Tanaka and Michihiro Sugano and George V. Vahouny and Linda L. Gallo},
  journal={Journal of lipid research},
  volume={29 12},
The extent and site(s) of inhibition of cholesterol absorption by plant sterols, sitosterol and fucosterol, were studied in rats. The intragastric administration of a single emulsified lipid meal containing 25 mg [3H]cholesterol and 25 mg of either sitosterol or fucosterol inhibited the lymphatic absorption of cholesterol by 57% and 41%, respectively, in 24 hr. Less than 2% of each plant sterol was absorbed in the 24-hr period. In contrast, neither plant sterol (50 microM) inhibited cholesterol… CONTINUE READING


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