Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress

@article{Leclercq1998InhibitionOC,
  title={Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress},
  author={I. Leclercq and J. Desager and Y. Horsmans},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1998},
  volume={64}
}
To investigate the effect of watercress on the metabolism of chlorzoxazone, an in vivo probe for CYP2E1, the oral pharmacokinetics of chlorzoxazone was studied in 10 healthy volunteers before and after a single ingestion of a watercress homogenate (50 gm). A third chlorzoxazone pharmacokinetic study was performed after a 1‐week treatment with isoniazid (300 mg/day), a well‐known CYP2E1 inhibitor. Ingestion of watercress or isoniazid did not affect the oral absorption of chlorzoxazone. The area… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Modulation of CYP2E1 activity by isoniazid in rapid and slow N-acetylators.
Inhibition and induction of cytochrome P4502E1‐catalyzed oxidation by isoniazid in humans
Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone.
In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians.
...
1
2
3
4
5
...