Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase.

  title={Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase.},
  author={Tatiana Okouneva and Olga Azarenko and Leslie Wilson and B. Littlefield and Mary Ann Jordan},
  journal={Molecular cancer therapeutics},
  volume={7 7},
Eribulin (E7389), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and microtubules. At low concentrations, it suppresses the growth phase of microtubule dynamic instability in interphase cells, arrests mitosis, and induces apoptosis, suggesting that suppression of spindle microtubule dynamics induces mitotic arrest. To further test this hypothesis, we measured the effects of eribulin on dynamics of centromeres and their attached… CONTINUE READING