Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner.

@article{Zhang2004InhibitionOC,
  title={Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner.},
  author={Zhensheng Zhang and Ulrike Protzer and Zongyi Hu and James Jacob and T. Jake Liang},
  journal={Journal of virology},
  year={2004},
  volume={78 9},
  pages={4566-72}
}
The X protein (HBX) of the hepatitis B virus (HBV) is not essential for the HBV life cycle in vitro but is important for productive infection in vivo. Our previous study suggests that interaction of HBX with the proteasome complex may underlie the pleiotropic functions of HBX. With the woodchuck model, we demonstrated that the X-deficient mutants of woodchuck hepatitis virus (WHV) are not completely replication defective, possibly behaving like attenuated viruses. In the present study, we… CONTINUE READING
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