Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1.

Abstract

The activation of the insulin-like growth factor 1 (IGF-1) receptor by its ligand plays a central role in the growth of most cell types. We have used the techniques of computational chemistry in order to design and synthesize several novel analogues of IGF-1. These analogues were able to inhibit the autophosphorylation of the IGF-1 receptor as well as the… (More)

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@article{Pietrzkowski1992InhibitionOC, title={Inhibition of cellular proliferation by peptide analogues of insulin-like growth factor 1.}, author={Zb Pietrzkowski and Dorothee Wernicke and P Porcu and B. A. Jameson and Renato Baserga}, journal={Cancer research}, year={1992}, volume={52 23}, pages={6447-51} }