Inhibition of cellular immune responses to encapsulated porcine islet xenografts by simultaneous blockade of two different costimulatory pathways.

@article{Safley2005InhibitionOC,
  title={Inhibition of cellular immune responses to encapsulated porcine islet xenografts by simultaneous blockade of two different costimulatory pathways.},
  author={Susan A Safley and Linda M. Kapp and Carol Tucker-Burden and Bernhard Hering and Judith A. Kapp and Collin J. Weber},
  journal={Transplantation},
  year={2005},
  volume={79 4},
  pages={409-18}
}
BACKGROUND Transplantation of human islets has been successful clinically. Since human islets are scarce, we are studying microencapsulated porcine islet xenografts in nonobese diabetic (NOD) mice. We have evaluated the cellular immune response in NOD mice with and without dual costimulatory blockade. METHODS Alginate-poly-L-lysine-encapsulated adult porcine islets were transplanted i.p. in untreated diabetic NODs and NODs treated with CTLA4-Ig to block CD28/B7 and with anti-CD154 mAb to… CONTINUE READING