Inhibition of cellular DNA synthesis by reovirus occurs through a receptor-linked signaling pathway that is mimicked by antiidiotypic, antireceptor antibody

@article{Gaulton1989InhibitionOC,
  title={Inhibition of cellular DNA synthesis by reovirus occurs through a receptor-linked signaling pathway that is mimicked by antiidiotypic, antireceptor antibody},
  author={Glen N. Gaulton and M ichael Greene},
  journal={The Journal of Experimental Medicine},
  year={1989},
  volume={169},
  pages={197 - 211}
}
Mammalian reovirus type 3 binds to a 67-kD surface glycoprotein on the membrane of neuronal cells. This interaction initiates the infective reovirus cycle. The physiological function of this virus receptor is not known, however, initial studies illustrate a striking structural and antigenic homology to the beta adrenergic receptor family. The earliest known… CONTINUE READING