Inhibition of cell surface MHC class II expression by Salmonella.

  title={Inhibition of cell surface MHC class II expression by Salmonella.},
  author={Erin K. Mitchell and Pietro Mastroeni and Adrian P. Kelly and John Trowsdale},
  journal={European journal of immunology},
  volume={34 9},
Peptide presentation by MHC molecules is an essential component of the adaptive immune response. To persist in a host, many pathogens have evolved strategies that interfere with MHC antigen-presentation. We show that in human cells harboring intracellular Salmonella, MHC class II cell surface expression was substantially reduced. The effect was specific for MHC class II as expression of additional surface receptors remained unchanged. We investigated the underlying mechanism and showed that… CONTINUE READING

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Salmonella regulates polyubiquitination and surface expression of MHC class II antigens.

Proceedings of the National Academy of Sciences of the United States of America • 2009
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