Inhibition of cell proliferation and dihydrofolate reductase by liposomes containing methotrexate-dimyristoylphosphatidylethanolamine derivatives and by the glycerophosphorylethanolamine analogs.

@article{Hashimoto1985InhibitionOC,
  title={Inhibition of cell proliferation and dihydrofolate reductase by liposomes containing methotrexate-dimyristoylphosphatidylethanolamine derivatives and by the glycerophosphorylethanolamine analogs.},
  author={K Hashimoto and Joan E. Loader and M. Knight and Stephen C. Kinsky},
  journal={Biochimica et biophysica acta},
  year={1985},
  volume={816 1},
  pages={
          169-78
        }
}
Synthesis of a novel phosphatidylcholine conjugated to docosahexaenoic acid and methotrexate that inhibits cell proliferation
TLDR
The synthesis and characterization of a lipophilic phosphatidylcholine containing the ω-3 fatty acid docosahexaenoic acid (DHA) and the cytotoxic drug methotrexate (MTX) is reported, suggesting the compound's potential use in cancer chemotherapy.
Release of Active Drug from Intracellular Liposomal Prodrug Depots in Macrophages Controlled by Liposome Composition
TLDR
The anticancer drug 5-fluoro-deoxyuridine (FUdR), which is frequently used in therapeutic treatment of liver metastases from colon tumors, is an example of such drugs that is rapidly eliminated from circulation and metabolized, mainly by the hepatocytes in the liver.
...
...

References

SHOWING 1-10 OF 11 REFERENCES
Elimination or rescue of cells in culture by specifically targeted liposomes containing methotrexate or formyl‐tetrahydrofolate.
TLDR
Methotrexate inhibits cellular proliferation by blocking formyl tetrahydrofolate (THF) production and covalently coupled to Staphylococcus aureus protein A bound specifically in vitro to cells pre‐incubated with relevant monoclonal antibodies, allowing the recovery of either a small proportion of cells not bearing a given antigen, or a smallportion of cells bearing agiven antigen, from heterogeneous cell populations.
Specific interaction of myeloma tumor cells with hapten-bearing liposomes containing methotrexate and carboxyfluorescein.
TLDR
Hapten-bearing liposomes containing methotrexate and the fluorescent solute carboxyfluorescein were incubated with murine myeloma tumor cells expressing surface immunoglobulin with affinity for the hapten and showed a patchy surface pattern, indicating intact liposome at the cell surface.
Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.
TLDR
Biochemical-pharmacological studies on the prepared compounds aided in establishing that the alpha- carboxyl grouping of the glutamate moiety contributes to the binding of MTX to dihydrofolate reductase while the gamma-carboxyl does not.
Interactions of immunoliposomes with target cells.
...
...