Inhibition of cell proliferation and dihydrofolate reductase by liposomes containing methotrexate-dimyristoylphosphatidylethanolamine derivatives and by the glycerophosphorylethanolamine analogs.

@article{Hashimoto1985InhibitionOC,
  title={Inhibition of cell proliferation and dihydrofolate reductase by liposomes containing methotrexate-dimyristoylphosphatidylethanolamine derivatives and by the glycerophosphorylethanolamine analogs.},
  author={K. Hashimoto and J. Loader and M. S. Knight and S. Kinsky},
  journal={Biochimica et biophysica acta},
  year={1985},
  volume={816 1},
  pages={
          169-78
        }
}
  • K. Hashimoto, J. Loader, +1 author S. Kinsky
  • Published 1985
  • Biology, Medicine
  • Biochimica et biophysica acta
  • Liposomes, which were prepared with the three methotrexate (MTX)-dimyristoylphosphatidylethanolamine (DMPE) derivatives described in the preceding paper, were tested for their ability to block proliferation of mouse 3T3 and L1210 cells. Tritiated deoxyuridine incorporation into DNA could be completely inhibited by liposomes sensitized with MTX-DMPE I (MTX-gamma-DMPE). Under similar conditions, liposomes containing MTX-DMPE II (MTX-alpha-DMPE) and MTX-DMPE III (MTX-alpha, gamma-diDMPE) produced… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 11 REFERENCES
    Interactions of immunoliposomes with target cells.
    • 128