Inhibition of cell growth and induction of apoptosis in non‐small cell lung cancer cells by delta‐tocotrienol is associated with notch‐1 down‐regulation

@article{Ji2011InhibitionOC,
  title={Inhibition of cell growth and induction of apoptosis in non‐small cell lung cancer cells by delta‐tocotrienol is associated with notch‐1 down‐regulation},
  author={Xiangming Ji and Zhiwei Wang and Andreea Geamanu and Fazlul H. Sarkar and Smiti Vaid Gupta},
  journal={Journal of Cellular Biochemistry},
  year={2011},
  volume={112}
}
Lung cancer is the leading cause of death among all cancers. Non‐small cell lung cancer accounts for 80% of lung cancer with a 5‐year survival rate of 16%. Notch pathway, especially Notch‐1 is up‐regulated in a subgroup of non‐small cell lung cancer patients. Since Notch‐1 signaling plays an important role in cell proliferation, differentiation, and apoptosis, down‐regulation of Notch‐1 may exert anti‐tumor effects. The objective of this study was to investigate whether delta‐tocotrienol, a… 
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