Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment.

@article{Verdaguer2004InhibitionOC,
  title={Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment.},
  author={Ester Verdaguer and Andr{\'e}s Jim{\'e}nez and Anna Maria Canudas and Elvira G. Jord{\`a} and Francesc X Sureda and Merc{\`e} Pall{\`a}s and Antoni Camins},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={308 2},
  pages={
          609-16
        }
}
  • Ester Verdaguer, Andrés Jiménez, +4 authors Antoni Camins
  • Published in
    The Journal of pharmacology…
    2004
  • Chemistry, Medicine
  • Kainic acid (KA)-induced neuronal damage and the protective effects of flavopiridol were studied in primary cultures of rat cerebellar granule cells (CGNs). When neurons were treated with 500 microM KA, the percentage of cells with condensed nuclei measured by nuclear counting increased by up to 55%. After flavopiridol treatment, an antitumoral drug that is a broad inhibitor of cyclin-dependent kinases, the percentage of condensed nuclei decreased by up to 26%. Furthermore, this KA-mediated… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 46 REFERENCES

    A (2002a) Kainic acid-induced neuronal cell death in cerebellar granule cells is not prevented by caspase inhibitors

    • E Verdaguer, E Garcı́a-Jordà, +7 authors Camins
    • Br J Pharmacol
    • 2002
    VIEW 10 EXCERPTS
    HIGHLY INFLUENTIAL

    E2F-1 induced apoptosis

    VIEW 6 EXCERPTS
    HIGHLY INFLUENTIAL

    Induction and modulation of cerebellar granule neuron death by E2F-1.

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL

    Excitotoxic and excitoprotective mechanisms

    VIEW 2 EXCERPTS