Inhibition of cell adhesion by xARVCF indicates a regulatory function at the plasma membrane.

@article{Reintsch2008InhibitionOC,
  title={Inhibition of cell adhesion by xARVCF indicates a regulatory function at the plasma membrane.},
  author={Wolfgang E. Reintsch and Craig A. Mandato and Pierre D. McCrea and François Fagotto},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2008},
  volume={237 9},
  pages={2328-41}
}
The cytoplasmic tail of cadherins is thought to regulate the strength and dynamics of cell-cell adhesion. Part of its regulatory activity has been attributed to a membrane-proximal region, the juxtamembrane domain (JMD), and its interaction with members of the p120 catenin subfamily. We show that titration of xARVCF, a member of this family, to the plasma membrane disrupts adhesion in the early embryo. Adhesion can be restored by coexpression of constitutively active Rac, suggesting that… CONTINUE READING

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