Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis.

Abstract

UNLABELLED Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells. However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin. Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with… (More)
DOI: 10.1158/1541-7786.MCR-13-0108

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