Inhibition of caveolar uptake, SV40 infection, and β1-integrin signaling by a nonnatural glycosphingolipid stereoisomer

@article{Singh2007InhibitionOC,
  title={Inhibition of caveolar uptake, SV40 infection, and β1-integrin signaling by a nonnatural glycosphingolipid stereoisomer},
  author={Raman Deep Singh and Eileen L. Holicky and Zhi-jie Cheng and Seong-Youl Kim and Christine L. Wheatley and David L. Marks and Robert Bittman and Richard E. Pagano},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={176},
  pages={895 - 901}
}
Caveolar endocytosis is an important mechanism for the uptake of certain pathogens and toxins and also plays a role in the internalization of some plasma membrane (PM) lipids and proteins. However, the regulation of caveolar endocytosis is not well understood. We previously demonstrated that caveolar endocytosis and beta1-integrin signaling are stimulated by exogenous glycosphingolipids (GSLs). In this study, we show that a synthetic GSL with nonnatural stereochemistry, beta-D-lactosyl-N… CONTINUE READING

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