Inhibition of cathepsin K for treatment of osteoporosis.

  title={Inhibition of cathepsin K for treatment of osteoporosis.},
  author={Steven Boonen and Elizabeth Rosenberg and Frank Claessens and Dirk Vanderschueren and Socrates E Papapoulos},
  journal={Current osteoporosis reports},
  volume={10 1},
Cathepsin K is the protease that is primarily responsible for the degradation of bone matrix by osteoclasts. Inhibitors of cathepsin K are in development for treatment of osteoporosis. Currently available antiresorptive drugs interfere with osteoclast function. They inhibit both bone resorption and formation, due to the coupling between these processes. Cathepsin K inhibitors, conversely, target the resorption process itself and may not interfere with osteoclast stimulation of bone formation… CONTINUE READING
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Effect of the cathepsin K inhibitor ONO-5334 on biochemical markers of bone turnover in the treatment of postmennopausal osteopenia or osteoporosis: 2year results from the OCEAN atudy

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Efficacy of ONO-5334, a cathepsin K inhibitor, on bone mass and strength in ovariectomized cynomolgus monkeys

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Efficacy of ONO-5334, a cathepsin K inhibitor, on bone turnover and cortical geometry in ovariectomized cynolmolgus monkeys

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