Inhibition of caspase-9 reduces chondrocyte apoptosis and proteoglycan loss following mechanical trauma.

Abstract

OBJECTIVE Chondrocyte death, a notable feature of osteoarthritis, may play a role in the initiation of cartilage degeneration. The present study was aimed at uncovering the nature and involvement of cell death in the initiation of cartilage degeneration induced by mechanical trauma. METHODS Articular cartilage discs obtained from healthy skeletally mature… (More)

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