Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor

@article{Conway1995InhibitionOC,
  title={Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor},
  author={James G. Conway and Jean A. Wakefield and R. H. Brown and Brian E. Marron and Les Sekut and Stephen A. Stimpson and Andy McElroy and J. Alan Menius and Jennifer Jeffreys and Richard L Clark},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={182},
  pages={449 - 457}
}
Considerable evidence has associated the expression of matrix metalloproteinases (MMPs) with the degradation of cartilage and bone in chronic conditions such as arthritis. Direct evaluation of MMPs' role in vivo has awaited the development of MMP inhibitors with appropriate pharmacological properties. We have identified butanediamide, N4-hydroxy-2-(2-methylpropyl)-N1-[2-[[2-(morpholinyl)ethyl]-,[S- (R*,S*)] (GI168) as a potent MMP inhibitor with sufficient solubility and stability to permit… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

A high throughput fluorogenic substrate for interstial collagenase ( MMP - 1 ) and gelatinase ( MMP - 90 )

  • H. G. Welgus, J. C. Sacchettini, W. T. Roswit, J. J. Jeffrey
  • Anal . Biochem .
  • 1993

Direct evidence for active metaUoproteinases mediating matrix degradation in interleukin 1 - stimulated human articular cartilage

  • G. DiPasquale
  • 1993

Similar Papers

Loading similar papers…