Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone.

@article{Kennedy1996InhibitionOC,
  title={Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone.},
  author={Jennifer Ann Kennedy and Steven Anthony Unger and John David Horowitz},
  journal={Biochemical pharmacology},
  year={1996},
  volume={52 2},
  pages={
          273-80
        }
}
The mechanism of the anti-anginal effect of perhexiline is unclear but appears to involve a shift in cardiac metabolism from utilization of fatty acid to that of carbohydrate. We tested the hypothesis that perhexiline inhibits the enzyme carnitine palmitoyltransferase-1 (CPT-1), which controls access of long chain fatty acids to the mitochondrial site of beta-oxidation. Perhexiline produced a concentration-dependent inhibition of CPT-1 in rat cardiac and hepatic mitochondria in vitro, with half… CONTINUE READING
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