Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism

  title={Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism},
  author={K. Jaudzems and J. Kuka and Aleksandrs Gutsaits and Kirils Zinovjevs and I. Kalvinsh and E. Liepinsh and M. Dambrova},
  journal={Journal of Enzyme Inhibition and Medicinal Chemistry},
  pages={1269 - 1275}
  • K. Jaudzems, J. Kuka, +5 authors M. Dambrova
  • Published 2009
  • Chemistry, Biology, Medicine
  • Journal of Enzyme Inhibition and Medicinal Chemistry
  • Carnitine acetyltransferase (CrAT; EC catalyzes the reversible transfer of acetyl groups between acetyl-coenzyme A (acetyl-CoA) and L-carnitine; it also regulates the cellular pool of CoA and the availability of activated acetyl groups. In this study, biochemical measurements, saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopy, and molecular docking were applied to give insights into the CrAT binding of a synthetic inhibitor, the cardioprotective drug… CONTINUE READING
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