Inhibition of cardiac two-pore-domain K+ (K2P) channels--an emerging antiarrhythmic concept.


Effective and safe pharmacological management of cardiac arrhythmia still constitutes a major clinical challenge. Outward potassium currents mediated by two-pore-domain potassium (K2P) channels promote repolarization of excitable cells. In the heart, inhibition or genetic inactivation of K2P currents results in action potential prolongation. Human K2P3.1… (More)
DOI: 10.1016/j.ejphar.2014.05.056


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