Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice.

@article{Hayakawa2003InhibitionOC,
  title={Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice.},
  author={Yukihiro Hayakawa and Madhulika Chandra and Wenfeng Miao and Jamshid Shirani and Joan Brown and Gerald W. Dorn and Robert C. Armstrong and Richard N Kitsis},
  journal={Circulation},
  year={2003},
  volume={108 24},
  pages={3036-41}
}
BACKGROUND Although the occurrence of cardiac myocyte apoptosis during heart failure has been documented, its importance in pathogenesis is unknown. Transgenic mice with cardiac-restricted overexpression of Galpha(q) exhibit a lethal, peripartum cardiomyopathy accompanied by apoptosis. To test whether apoptosis is causally linked to heart failure, we assessed whether inhibiting this cell death would improve left ventricular function and survival in the Galpha(q) peripartum cardiomyopathy model… CONTINUE READING
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Functional consequences of caspase activation in cardiac myocytes

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