Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice.

@article{Babij1998InhibitionOC,
  title={Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice.},
  author={P Babij and George R. Askew and Bart W Nieuwenhuijsen and C M Su and T R Bridal and Brian Jow and Thomas M. Argentieri and John M. Kulik and LOUIS J. DEGENNARO and W Spinelli and Thomas J. Colatsky},
  journal={Circulation research},
  year={1998},
  volume={83 6},
  pages={668-78}
}
Mutations in the HERG gene are linked to the LQT2 form of the inherited long-QT syndrome. Transgenic mice were generated expressing high myocardial levels of a particularly severe form of LQT2-associated HERG mutation (G628S). Hearts from G628S mice appeared normal except for a modest enlargement seen only in females. Ventricular myocytes isolated from adult wild-type hearts consistently exhibited an inwardly rectifying E-4031-sensitive K+ current resembling the rapidly activating cardiac… CONTINUE READING

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