Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation

@article{Scholz2005InhibitionOC,
  title={Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation},
  author={Eberhard P. Scholz and Edgar Zitron and Claudia Kiesecker and Sonja C. Lueck and Dierk Thomas and Sven Kathoefer and Volker A. W. Kreye and Hugo A. Katus and Johann Kiehn and Wolfgang H. Sch{\"o}ls and Christoph Karle},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2005},
  volume={371},
  pages={516-525}
}
Flavonoids are naturally occurring food ingredients that have been associated with reduced cardiovascular mortality in epidemiological studies. In a previous study, we demonstrated for the first time that flavonoids are inhibitors of cardiac human ether-à-go-go-related gene (HERG) channels. Furthermore, we observed that grapefruit juice induced mild QTc prolongation in healthy subjects. HERG blockade by grapefruit flavonoid naringenin is most likely to be the mechanism underlying this effect… CONTINUE READING
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