Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach.

@article{Yamane1995InhibitionON,
  title={Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach.},
  author={Tomojiro Yamane and Toshio Takahashi and Katsuya Kuwata and Kazuhiko Oya and Masao Inagake and Yoshitaka Kitao and Musami Suganuma and Hirota Fujiki},
  journal={Cancer research},
  year={1995},
  volume={55 10},
  pages={2081-4}
}
Recently, an epidemiological study showed a lower risk of gastric cancer among people who consume a large amount of green tea. (-)-Epigallocatechin gallate (EGCG), one of the main constituents of green tea, inhibited tumor promotion by teleocidin in a two-stage carcinogenesis experiment with the use of mouse skin. The inhibitory effect of EGCG on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced carcinogenesis of the glandular stomach in rats was examined. The percentage of tumor-bearing rats… CONTINUE READING
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