Inhibition of carbonic anhydrase by pirenzepine.

  title={Inhibition of carbonic anhydrase by pirenzepine.},
  author={Ioan I. Puscas and Gy. M Buz{\'a}s and P{\'e}ter Sur{\'a}nyi and M Domuţă},
  journal={International journal of clinical pharmacology, therapy, and toxicology},
  volume={19 2},
Previous work of the authors established a parallelism between gastric mucosa carbonic anhydrase (CA) activity and the values of acid secretion. It was shown that histamine (Ht) is a physiological activator of CA, and that there could be histaminic H2 receptors located on the molecule of CA. Pirenzepine (GZ) is a drug recently introduced in the therapy of gastroduodenal ulcer (GDU). Although its effect of decreasing acid secretion is clinically known, its mechanism of action remains uncertain… CONTINUE READING

Topics from this paper.


Publications citing this paper.

Similar Papers

Loading similar papers…