Inhibition of carbonic anhydrase by pirenzepine.

@article{Puscas1981InhibitionOC,
  title={Inhibition of carbonic anhydrase by pirenzepine.},
  author={Ioan I. Puscas and Gy. M Buz{\'a}s and P{\'e}ter Sur{\'a}nyi and M Domuţă},
  journal={International journal of clinical pharmacology, therapy, and toxicology},
  year={1981},
  volume={19 2},
  pages={
          75-7
        }
}
Previous work of the authors established a parallelism between gastric mucosa carbonic anhydrase (CA) activity and the values of acid secretion. It was shown that histamine (Ht) is a physiological activator of CA, and that there could be histaminic H2 receptors located on the molecule of CA. Pirenzepine (GZ) is a drug recently introduced in the therapy of gastroduodenal ulcer (GDU). Although its effect of decreasing acid secretion is clinically known, its mechanism of action remains uncertain… CONTINUE READING

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