Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).

@article{Sinclair2010InhibitionOC,
  title={Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).},
  author={Simon R. Sinclair and Stefanie A. Kane and Bart J. Van der Schueren and Alan J. Xiao and Kenneth J Willson and Janet M. Boyle and Inge de Lepeleire and Yang Xu and Lisa A. Hickey and William S. Denney and Chi-Chung Li and John S Palcza and Floris H. M. Vanmolkot and Marleen Depr{\'e} and Anne van Hecken and Martin G. Murphy and Tony W. Ho and Jay N de Hoon},
  journal={British journal of clinical pharmacology},
  year={2010},
  volume={69 1},
  pages={
          15-22
        }
}
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Calcitonin gene-related peptide (CGRP) was first described as a potent vasodilator. * CGRP is also increasingly recognized as a key player in the pathophysiology of migraine, and CGRP receptor antagonists potentially offer a new approach for treating migraine. * A novel pharmacodynamic assay to measure CGRP receptor antagonist activity non-invasively in humans has been developed, which involves measuring the increase in dermal blood flow induced by… CONTINUE READING
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