Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.

@article{Srivastava2014InhibitionOC,
  title={Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.},
  author={Nishi Srivastava and Rahul K. Kollipara and Dinesh Kumar Singh and Jessica A. Sudderth and Zeping Hu and Hien P Nguyen and Shan Wang and Caroline G. Humphries and Ryan M Carstens and Kenneth Edward Huffman and Ralph J DeBerardinis and Ralf Kittler},
  journal={Cell metabolism},
  year={2014},
  volume={20 4},
  pages={650-61}
}
The nuclear receptor peroxisome-proliferation-activated receptor gamma (PPARγ), a transcriptional master regulator of glucose and lipid metabolism, inhibits the growth of several common cancers, including lung cancer. In this study, we show that the mechanism by which activation of PPARγ inhibits proliferation of lung cancer cells is based on metabolic changes. We found that treatment with the PPARγ agonist pioglitazone triggers a metabolic switch that inhibits pyruvate oxidation and reduces… CONTINUE READING
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Inhibition of Cancer Cell Proliferation by PPARg Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels, Cell Metabolism

  • Srivastava
  • 2014
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