• Corpus ID: 7824075

Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis.

  title={Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis.},
  author={David Y. Zhang and Josephine Wu and Fei Ye and Lingru Xue and Shiquang Jiang and Jizu Yi and Wandi Zhang and Huachen Wei and Max Sung and Wayne Wang and Xiaoping Li},
  journal={Cancer research},
  volume={63 14},
Scutellaria baicalensis is a widely used Chinese herbal medicine that has been used historically in anti-inflammatory and anticancer therapy. The purpose of this study is to verify its anticancer activity on head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo and to investigate its effect on cyclooxygenase-2 (COX-2), which converts arachidonic acid to prostaglandin E(2) (PGE(2)) and is highly expressed in HNSCC. Two human HNSCC cell lines (SCC-25 and KB) and a nontumorigenic cell… 

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