Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.

@article{Ramer2008InhibitionOC,
  title={Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.},
  author={R. Ramer and B. Hinz},
  journal={Journal of the National Cancer Institute},
  year={2008},
  volume={100 1},
  pages={
          59-69
        }
}
  • R. Ramer, B. Hinz
  • Published 2008
  • Biology, Medicine
  • Journal of the National Cancer Institute
BACKGROUND Cannabinoids, in addition to having palliative benefits in cancer therapy, have been associated with anticarcinogenic effects. Although the antiproliferative activities of cannabinoids have been intensively investigated, little is known about their effects on tumor invasion. METHODS Matrigel-coated and uncoated Boyden chambers were used to quantify invasiveness and migration, respectively, of human cervical cancer (HeLa) cells that had been treated with cannabinoids (the stable… Expand
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
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