Inhibition of calcium influx in isolated adult rat heart cells by ATP depletion.

@article{Haworth1987InhibitionOC,
  title={Inhibition of calcium influx in isolated adult rat heart cells by ATP depletion.},
  author={Robert Haworth and Atilla B. Goknur and Douglas R. Hunter and Julia O Hegge and H A Berkoff},
  journal={Circulation research},
  year={1987},
  volume={60 4},
  pages={586-94}
}
Using 45Ca, indo1, and quin2, calcium uptake was measured in isolated quiescent adult rat heart cells under different metabolic conditions. Exposure of cells in a medium containing 1 mM CaCl2 to rotenone and uncoupler resulted in adenosine triphosphate (ATP) depletion from 17.08 +/- 2.26 to 0.63 +/- 0.11 nmol/mg within 8 minutes, and the cells went into contracture. In this time, the cells lost 1.65 +/- 0.1 nmol Ca/mg of total rapidly exchangeable cellular calcium, and the level of free… CONTINUE READING

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Uglesity A: Na-Ca exchange contributes to increase of cytosolic Ca concentration during depolarization in heart muscle

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