Inhibition of calcium-dependent NMDA receptor current rundown by calbindin-D28k.

  title={Inhibition of calcium-dependent NMDA receptor current rundown by calbindin-D28k.},
  author={Carol Seals Price and Gordon L. Rintoul and Kenneth G Baimbridge and Lynn A Raymond},
  journal={Journal of neurochemistry},
  volume={72 2},
NMDA receptors are regulated by several different calcium-dependent processes. To determine if the presence of the intracellular calcium-binding protein calbindin-D28k can influence the calcium regulation of NMDA receptor activity, human embryonic kidney 293 cells were co-transfected with cDNAs for NMDA receptor subunits and calbindin. Recordings were made using the nystatin perforated patch technique to preserve intracellular contents. When compared with control cells (transfected with cDNA… CONTINUE READING


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