Inhibition of calcium currents in cultured rat dorsal root ganglion neurones by (-)-baclofen.

@article{Dolphin1986InhibitionOC,
  title={Inhibition of calcium currents in cultured rat dorsal root ganglion neurones by (-)-baclofen.},
  author={Annette C Dolphin and Roderick H. Scott},
  journal={British journal of pharmacology},
  year={1986},
  volume={88 1},
  pages={213-20}
}
Voltage-dependent inward calcium currents (ICa) activated in cultured rat dorsal root ganglion neurones were reversibly reduced in a dose-dependent manner by (-)-baclofen (10 microM to 100 microM). Baclofen (100 microM) reduced the calcium-dependent slow outward potassium current (IK(Ca)). This current was abolished in calcium-free medium and by 300 microM cadmium chloride. The action of baclofen on IK(Ca) was reduced when the calcium concentration in the medium was increased from 5 mM to 30 mM… CONTINUE READING
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The adenosine analogue 2 - chloroadenosine inhibits Ba 2 + currents in rat dorsal root ganglion neurones in culture

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Two types of calcium channels in the somatic membrane of new born rat dorsal root

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