Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.

@article{Zhao2010InhibitionOC,
  title={Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.},
  author={Wei-qin Zhao and Francesca Santini and Robert Breese and Dave W Ross and Xiaohua Douglas Zhang and David J. Stone and Marc Ferrer and Matthew T Townsend and Abigail L Wolfe and Matthew A. Seager and Gene G. Kinney and Paul J. Shughrue and William J. Ray},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 10},
  pages={7619-32}
}
Synaptic degeneration, including impairment of synaptic plasticity and loss of synapses, is an important feature of Alzheimer disease pathogenesis. Increasing evidence suggests that these degenerative synaptic changes are associated with an accumulation of soluble oligomeric assemblies of amyloid beta (Abeta) known as ADDLs. In primary hippocampal cultures ADDLs bind to a subpopulation of neurons. However the molecular basis of this cell type-selective interaction is not understood. Here, using… CONTINUE READING
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