Inhibition of calcifying nodule formation in cultured porcine aortic valve cells by nitric oxide donors.

@article{Kennedy2009InhibitionOC,
  title={Inhibition of calcifying nodule formation in cultured porcine aortic valve cells by nitric oxide donors.},
  author={Jennifer A Kennedy and Xiang Wei Hua and Kumaril Mishra and Geraldine A Murphy and Anke Claudia Rosenkranz and John David Horowitz},
  journal={European journal of pharmacology},
  year={2009},
  volume={602 1},
  pages={28-35}
}
Calcific aortic stenosis displays some similarities to atherosclerosis including evidence of endothelial dysfunction. Whether nitric oxide (NO), which is produced by valvular endothelium, has direct protective effects extending to calcification processes in aortic valve cells has not previously been examined. In vitro calcifying nodules in porcine aortic valve interstitial cell cultures, formed in response to transforming growth factor-beta1 (TGF-beta1) 5 ng/ml, were inhibited by NO donors DETA… CONTINUE READING

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