Inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscles cells.

@article{Sun2010InhibitionOC,
  title={Inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscles cells.},
  author={Xiu-zhen Sun and Zong-fang Li and Yun Liu and Ping Fang and Man-xiang Li},
  journal={Clinical and experimental pharmacology & physiology},
  year={2010},
  volume={37 3},
  pages={362-7}
}
1. It has been shown that the beneficial effects of phosphodiesterase (PDE) 5 inhibition on pulmonary hypertension (PH) are associated with the induction of vascular relaxation and suppression of the proliferation of pulmonary artery smooth muscle cells (PASMC). In the present study, we investigated whether PDE5 inhibition affects the production and/or secretion of matrix metalloproteinases (MMPs) in PASMC, resulting in extracellular matrix remodelling in the pulmonary vasculature and, thus… CONTINUE READING
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