Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.

Abstract

The cAMP response element-binding protein (CREB) is a critical integrator of neural plasticity that is responsive in a brain region-specific manner to a variety of environmental and pharmacological stimuli, including widely prescribed antidepressant medications. We developed inducible transgenic lines of mice that express either CREB or a dominant-negative… (More)

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@article{Newton2002InhibitionOC, title={Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.}, author={Samuel Sathyanesan Newton and Johannes Thome and Tanya L. Wallace and Yukihikko Shirayama and Lee Schlesinger and Norio Sakai and Jingshan Chen and Rachael Lee Neve and Eric J Nestler and Ronald Stanton Duman}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2002}, volume={22 24}, pages={10883-90} }