Inhibition of cAMP-dependent protein kinase A: a novel cyclo-oxygenase-independent effect of non-steroidal anti-inflammatory drugs in adipocytes.

@article{Pia2007InhibitionOC,
  title={Inhibition of cAMP-dependent protein kinase A: a novel cyclo-oxygenase-independent effect of non-steroidal anti-inflammatory drugs in adipocytes.},
  author={Martha Zentella de Pi{\~n}a and H{\'e}ctor V{\'a}zquez-Meza and Concepci{\'o}n Agundis and Mohamed Al{\'i} Pereyra and Juan Pablo Pardo and Rafael Villalobos-Molina and Enrique Pi{\~n}a},
  journal={Autonomic & autacoid pharmacology},
  year={2007},
  volume={27 2},
  pages={85-92}
}
1. Non-steroidal anti-inflammatory drugs (NSAIDs) [acetylsalicylic acid (ASS), naproxen, nimesulide and piroxicam] decreased adrenaline- or dibutyryl cAMP-stimulated glycerol release in isolated adipocytes. We aimed to determine the mechanism of this NSAIDs action. 2. Non-steroidal anti-inflammatory drugs decreased cAMP-dependent protein kinase A (PKA) activity in rat adipocyte lysates and in a commercial bovine heart PKA holoenzyme. If added before cAMP, NSAIDs impaired PKA activation by the… CONTINUE READING