Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury

@article{Lee2004InhibitionOC,
  title={Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury},
  author={Hui Su Lee and Hee Jae Kim and Chang Sook Moon and Young Hae Chong and Jihee Lee Kang},
  journal={Respiratory Research},
  year={2004},
  volume={5},
  pages={23 - 23}
}
BACKGROUND Although in vitro studies have determined that the activation of mitogen-activated protein (MAP) kinases is crucial to the activation of transcription factors and regulation of the production of proinflammatory mediators, the roles of c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in acute lung injury have not been elucidated. METHODS Saline or lipopolysaccharide (LPS, 6 mg/kg of body weight) was administered intratracheally with a 1-hour… CONTINUE READING