Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest.

@article{Kuntzen2005InhibitionOC,
  title={Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest.},
  author={Christian Kuntzen and Niluefer Sonuc and Enrico Narciso De Toni and Christine Opelz and Simon R. Mucha and Alexander L Gerbes and S{\"o}ren T. Eichhorst},
  journal={Cancer research},
  year={2005},
  volume={65 15},
  pages={6780-8}
}
Loss of susceptibility to apoptosis signals is a crucial step in carcinogenesis. Therefore, sensitization of tumor cells to apoptosis is a promising therapeutic strategy. c-Jun-N-terminal-kinases (JNK) have been implicated in stress-induced apoptosis, but may also contribute to survival signaling. Here we show that CD95-induced apoptosis is augmented by the JNK inhibitor SP600125 and small interfering RNA directed against JNK1/2. SP600125 potently inhibited methyl methane sulfonate-induced… CONTINUE READING
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A Novel AP-1 element in the CD95 ligand promoter is required for JNK Suppresses CD95-Induced Apoptosis www.aacrjournals.org

  • ST Eichhorst, M Muller, M Li-Weber, H SchulzeBergkamen, P Angel, PH. Krammer
  • Cancer Res
  • 2005
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