Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice.

Abstract

Atherosclerosis begins as local inflammation of arterial walls at sites of disturbed flow, such as vessel curvatures and bifurcations with low shear stress. c-Jun NH₂-terminal kinase (JNK) is a major regulator of flow-dependent gene expression in endothelial cells in atherosclerosis. However, little is known about the in vivo role of JNK in low shear stress… (More)
DOI: 10.2119/molmed.2011.00073

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Cite this paper

@article{Wang2011InhibitionOC, title={Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice.}, author={Juan Wang and Feng An and Wei Zhang and Lei Gong and Shu Jian Wei and Wei Qin and Xu Wang and Yu Zhao and Yun Zhang and Cheng Zhang and Ming-Xiang Zhang}, journal={Molecular medicine}, year={2011}, volume={17 9-10}, pages={990-9} }