Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression.

@article{Iliopoulos2007InhibitionOB,
  title={Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression.},
  author={Dimitrios C. Iliopoulos and Muller Fabbri and Teresa Druck and Haiyan Qin and Shuang-yin Han and Kay F Huebner},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 1},
  pages={268-74}
}
PURPOSE The WWOX gene is down-regulated in breast cancer and loss of Wwox expression correlates with important clinical features of breast cancer. Thus, we have examined the effect of restoration of Wwox expression in breast cancer-derived cells. EXPERIMENTAL DESIGN Wwox protein expression was restored by the following: (a) infection with a recombinant adenovirus carrying WWOX cDNA (Ad-WWOX) or (b) treatment with the DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, to activate the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Induction of apoptosis in p 16 INK 4 A mutant cell lines by adenovirus - mediated overexpression of p 16 INK 4 A protein

M Kim, Y Katayose, L Rojanala
Oncogene • 2006

Reviewof theclinicalexperience with 5 - aza - cytidine and 5 - aza - 2 ¶ - deoxycytidine in solid tumors

WeberJS AparicioA
Cancer Res • 2005

Similar Papers

Loading similar papers…