Inhibition of branched-chain amino acid degradation by ketone bodies.

  • Sverre Landaas
  • Published 1977 in
    Scandinavian journal of clinical and laboratory…

Abstract

The present study deals with mechanisms for the accumulation of intermediates in the catabolism of branched-chain amino acids in patients with ketoacidosis. Two different systems have been developed to measure the degradation rates of leucine and valine intermediates in rat liver mitochondria. 3-Hydroxybutyrate was found to inhibit the conversion of… (More)

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