Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias.

@article{Dias2001InhibitionOB,
  title={Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias.},
  author={S{\'e}rgio Luiz Vaz Dias and Koichi Hattori and Beate Heissig and Zhenping Zhu and Ying Wu and Larry Witte and Daniel J. Hicklin and Masatoshi Tateno and Peter Bohlen and Malcolm A. S. Moore and Shahin Rafii},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 19},
  pages={10857-62}
}
Antiangiogenic agents block the effects of tumor-derived angiogenic factors (paracrine factors), such as vascular endothelial growth factor (VEGF), on endothelial cells (EC), inhibiting the growth of solid tumors. However, whether inhibition of angiogenesis also may play a role in liquid tumors is not well established. We recently have shown that certain leukemias not only produce VEGF but also selectively express functional VEGF receptors (VEGFRs), such as VEGFR-2 (Flk-1, KDR) and VEGFR1 (Flt1… CONTINUE READING

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