Inhibition of bone resorption in vitro by a cartilage-derived anticollagenase factor.

@article{Horton1978InhibitionOB,
  title={Inhibition of bone resorption in vitro by a cartilage-derived anticollagenase factor.},
  author={John E Horton and Frederick H. Wezeman and Klaus E. Kuettner},
  journal={Science},
  year={1978},
  volume={199 4335},
  pages={1342-5}
}
A cartilage-derived factor containing a specific collagenous inhibitor was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. Morphologic and quantitative histometric examination revealed that this factor modulates osteoclastic activities.