Inhibition of biliary bicarbonate secretion in ethinyl estradiol-induced cholestasis is not associated with impaired activity of the Cl-/HCO-3 exchanger in the rat.

@article{Alvaro1997InhibitionOB,
  title={Inhibition of biliary bicarbonate secretion in ethinyl estradiol-induced cholestasis is not associated with impaired activity of the Cl-/HCO-3 exchanger in the rat.},
  author={Domenico Alvaro and Alessandro Gigliozzi and Christophe Piat and Ligia De Carli and Flavia Fraioli and Riccardo Romeo and Chiara Francia and Adolf F Attili and Livio Capocaccia},
  journal={Journal of hepatology},
  year={1997},
  volume={26 1},
  pages={146-57}
}
BACKGROUND/AIMS Bicarbonate is a major component of bile salt independent bile flow, which is impaired in ethinyl estradiol (EE)-cholestasis. To examine this subject in EE-cholestasis, we studied: 1) basal and glucagon-stimulated biliary bicarbonate secretion both in vivo and in the isolated perfused rat liver (IPRL); 2) H+/HCO-3 transport processes in isolated rat hepatocyte couplets. METHODS Rats received EE (5 mg.kg b.w.-1) for 5 days. Intracellular pH (pHi) was measured (BCECF-AM) using a… CONTINUE READING