Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing.

Abstract

There is strong evidence in the clinical literature to suggest that elevated lead (Pb) exposure impairs fracture healing. Since Pb has been demonstrated to inhibit bone formation, and Wnt signaling is an important anabolic pathway in chondrocyte maturation and endochondral ossification, we investigated the impact of Wnt therapy on Pb-exposed mice undergoing… (More)
DOI: 10.1002/jor.22677

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