Inhibition of beta-adrenoceptor agonist relaxation of airway smooth muscle by Ca(2+)-activated K+ channel blockers.

Abstract

In isolated guinea pig trachea contracted by 0.5 mM acetylcholine, the cumulative relaxant concentration-response curves to the beta 2-adrenoceptor agonist, salbutamol, were shifted to the right by depolarizing concentrations of KCl, as well as by charybdotoxin, iberiotoxin and tetraethylammonium ion, which are antagonists of the high-conductance Ca(2… (More)

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@article{Huang1993InhibitionOB, title={Inhibition of beta-adrenoceptor agonist relaxation of airway smooth muscle by Ca(2+)-activated K+ channel blockers.}, author={James C Huang and Mar{\'i}a Luisa Serrano Garc{\'i}a and John Reuben and G J Kacsorowski}, journal={European journal of pharmacology}, year={1993}, volume={235 1}, pages={37-43} }